Proton pump inhibitors for Gastric symptoms
Proton Pump Inhibitors (PPIs) are medications which reduce the production of acid by blocking the enzyme in the wall of the stomach which produces acid (necessary for the digestion of food in the stomach). However, excess production of this acid is associated with the formation of most ulcers in the oesophagus, stomach, and duodenum and causing Gastroesophageal Reflux Disease (also known as GERD). It may also be used in combination with antibiotics to treat Helicobacter Pylori (H. Pylori) a bacteria which is associated with gastric ulcers.
Formulations of PPI available include:
- Lansoprazole (Prevacid)
- Rabeprazole (Pariet)
- Pantoprazole (Controloc)
- Esomeprazole (Nexium)
- Dexlansoprazole (Dexilant)
Suggested PPI regime
Your doctor will recommend the medication schedule based on your condition. Remember than everyone’s condition is different so avoid self medication. Here is a general guide when taking PPIs;
- Should be taken 30-60 minutes before meals
- Should NOT be taken long term
- Should NOT be taken with H2 antagonists
- Can be taken with adjuvant therapy such as antacids or alginates
- Aim for lowest effective dose
- Beware of long term overuse
|GERD at diagnosis||Once daily||4-8 weeks|
|Maintenance GERD||Once daily||As directed|
|Symptomatic GERD||Once daily||4 weeks & thereafter on demand|
|Gastric Ulcer||Once daily||8 weeks|
|H Pylori Eradication||Twice daily||7-14 days|
There are side effects with any medication and as such it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated. Long term use can be associated with increased risk of fractures, kidney disease, pneumonia and Vitamin B12 deficiency. The most common side effects (usually mild and therefore easily tolerated) of PPIs are:
- Diarrhoea or constipation
- Nausea or vomiting
Discuss the treatment regime with your doctor or pharmacist to use your medication safely. AVOID self-medication
Disclaimer. TELEME blog posts contains general information about health conditions and treatments. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. The information is not advice and should not be treated as such.
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